Dyslipidemia_Things to consider_Can Some Medications Affect Cholesterol Levels

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CAN SOME MEDICATIONS AFFECT CHOLESTEROL LEVELS

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Heart Health

CAN SOME MEDICATIONS AFFECT CHOLESTEROL LEVELS

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Yes, numerous medications and medication classes have been shown to disturb the lipid profile. Some are listed below: 1

·        Birth control pills might increase triglycerides levels to up to 40%, depending on the type and the progestin/estrogen dosage.1,2

·        Oral anabolic steroids, indicated for endometriosis, can result in reduction in “(HDL), good cholesterol” by up to 50% and increase in “(LDL), bad cholesterol” by 10-40%.1,2

·        Beta blockers, prescribed in high blood pressure, typically raises levels of triglycerides from 10 to 40%, while lowering HDL levels by approximately 5 to 20%, depending on dose and specific drug. Newer beta blockers are less likely to affect your cholesterol levels. 1,2,3

·        High-dose thiazide diuretics (≥50 mg/day), commonly prescribed for high blood pressure, has been connected with increased triglyceride levels by 5-15% and LDL-C levels by approximately 10%. 1,2,3

Normally, discontinuing the use of the medication, or replacing it with an equivalent medication will lead to normal cholesterol levels. In case no equivalent therapy is available monitoring of serum lipid levels is vital. 1, 2

References:

1.       Herink, M. Medication Induced Changes in Lipid and Lipoproteins, 2018 Available at: https://www.ncbi.nlm.nih.gov/books/NBK326739/ Last accessed: 24/06/2019

2.       Lallanilla, M. Can Diseases or Drugs Cause High Cholesterol? 2019. Available at: https://www.verywellhealth.com/can-diseases-or-drugs-cause-high-cholesterol-3571690 Last accessed: 24/06/2019

3.       Sheps, SG. Blood pressure medications: Can they raise my triglycerides? Mayo Clinic. 2019. Available at: https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/expert-answers/blood-pressure-medications/faq-20057975 Last accessed: 22/06/2019